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MAST2

MAST2 (Microtubule Associated Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with MAST2 include Breast Mucinous Carcinoma. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST4.

Full Name

microtubule associated serine/threonine kinase 2

Function

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).

Biological Process

Cytoskeleton organization Source: GO_Central
Intracellular signal transduction Source: GO_Central
Peptidyl-serine phosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Regulation of interleukin-12 production Source: UniProtKB
Spermatid differentiation Source: UniProtKB

Cellular Location

Cytoskeleton
Plasma membrane
Cell membrane
Note: Recruited to the sub-membranous area on interaction with CDHR2.

PTM

Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).

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Anti-MAST2 antibodies

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Mouse Anti-MAST2 Recombinant Antibody (3F9) (CBMAB-A5312-LY)

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Target: MAST2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F9

Application*: WB, E

Mouse Anti-MAST2 Recombinant Antibody (CBFYM-1749) (CBMAB-M1917-FY)

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Target: MAST2

Host: Mouse

Specificity: Human

Clone: CBFYM-1749

Application*: WB, IP, IF, E

Mouse Anti-MAST2 (AA 1482-1798 ) Recombinant Antibody (CBFYM-1747) (CBMAB-M1915-FY)

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Target: MAST2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1747

Application*: WB

Mouse Anti-MAST2 Recombinant Antibody (CBFYM-0582) (CBMAB-M0711-FY)

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Target: MAST2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-0582

Application*: E, WB

Human Recombinant MAST2, Active protein, GST Tag (V2LY-0526-LY5469)

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Target: MAST2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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