MAST2

MAST2 (Microtubule Associated Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with MAST2 include Breast Mucinous Carcinoma. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAST4.
Full Name
microtubule associated serine/threonine kinase 2
Function
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).
Biological Process
Cytoskeleton organization Source: GO_Central
Intracellular signal transduction Source: GO_Central
Peptidyl-serine phosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Regulation of interleukin-12 production Source: UniProtKB
Spermatid differentiation Source: UniProtKB
Cellular Location
Cytoskeleton
Plasma membrane
Cell membrane
Note: Recruited to the sub-membranous area on interaction with CDHR2.
PTM
Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).
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Anti-MAST2 antibodies

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Mouse Anti-MAST2 Recombinant Antibody (3F9) (CBMAB-A5312-LY)

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Target: MAST2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F9
Application*: WB, E
Datasheet SDS

Mouse Anti-MAST2 Recombinant Antibody (CBFYM-1749) (CBMAB-M1917-FY)

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Target: MAST2
Host: Mouse
Specificity: Human
Clone: CBFYM-1749
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-MAST2 (AA 1482-1798 ) Recombinant Antibody (CBFYM-1747) (CBMAB-M1915-FY)

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Target: MAST2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1747
Application*: WB
Datasheet SDS

Mouse Anti-MAST2 Recombinant Antibody (CBFYM-0582) (CBMAB-M0711-FY)

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Target: MAST2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0582
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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