METAP1
METAP1 (Methionyl Aminopeptidase 1) is a Protein Coding gene. Among its related pathways are Phototransduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hydrolase activity and metalloexopeptidase activity. An important paralog of this gene is METAP1D.
Full Name
METHIONYL AMINOPEPTIDASE 1
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
Biological Process
N-terminal protein amino acid modification Source: HGNC-UCL
Peptidyl-methionine modification Source: HGNC-UCL
Platelet aggregation Source: UniProtKB
Protein initiator methionine removal Source: UniProtKB-UniRule
Regulation of translation Source: HGNC-UCL
Peptidyl-methionine modification Source: HGNC-UCL
Platelet aggregation Source: UniProtKB
Protein initiator methionine removal Source: UniProtKB-UniRule
Regulation of translation Source: HGNC-UCL
Cellular Location
Cytoplasm
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Anti-METAP1 antibodies
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Target: METAP1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYM-2108
Application*: WB, IP, IF, E
Target: METAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0626
Application*: WB
Target: METAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0096
Application*: E, WB
Target: METAP1
Sensitivity: 0.017 ng/mL
Detection Range: 0.05-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: METAP1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 52-386
Tag: His Tag
Target: METAP1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-272
Tag: hFc Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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