MOGAT3

Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM

Full Name

monoacylglycerol O-acyltransferase 3

Function

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).

Biological Process

Glycerol metabolic process Source: UniProtKB-KW
Lipid metabolic process Source: GO_Central
Monoacylglycerol biosynthetic process Source: UniProtKB
Triglyceride biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
perinuclear region

PTM

Ubiquitinated. Ubiquitination leads to proteasomal degradation.