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MTHFD2

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Full Name
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase
Function
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
Biological Process
Folic acid metabolic process Source: Reactome
Tetrahydrofolate interconversion Source: GO_Central
Tetrahydrofolate metabolic process Source: UniProtKB
Cellular Location
Mitochondrion
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Anti-MTHFD2 antibodies

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Rabbit Anti-MTHFD2 Recombinant Antibody (D8W9U) (CBMAB-CP1599-LY)

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Target: MTHFD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8W9U
Application*: WB, IP
Datasheet SDS

Mouse Anti-MTHFD2 Recombinant Antibody (4G7-2G3) (CBMAB-A5662-LY)

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Target: MTHFD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G7-2G3
Application*: WB, E
Datasheet SDS

Mouse Anti-MTHFD2 (AA 16-344) Recombinant Antibody (CBFYM-2738) (CBMAB-M2931-FY)

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Target: MTHFD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2738
Application*: E, P, WB
Datasheet SDS

Mouse Anti-MTHFD2 (AA 16-345) Recombinant Antibody (CBFYM-0508) (CBMAB-M0636-FY)

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Target: MTHFD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0508
Application*: E, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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