MXD4

This gene is a member of the MAD gene family. The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Full Name
MXD4
Function
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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Anti-MXD4 antibodies

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Mouse Anti-MXD4 Antibody (2B6) (CBMAB-0685-YC)

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Target: MXD4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2B6
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-MXD4 Recombinant Antibody (CBFYM-2860) (CBMAB-M3053-FY)

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Target: MXD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2860
Application*: WB
Datasheet SDS

Mouse Anti-MXD4 Recombinant Antibody (CBFYM-2859) (CBMAB-M3052-FY)

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Target: MXD4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2859
Application*: WB, IH
Datasheet SDS

Mouse Anti-MXD4 Recombinant Antibody (CBFYM-2858) (CBMAB-M3051-FY)

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Target: MXD4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2858
Application*: WB, IH, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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