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Mouse Anti-MXD4 Recombinant Antibody (CBFYM-2858) (CBMAB-M3051-FY)

This product is mouse antibody that recognizes MXD4. The antibody CBFYM-2858 can be used for immunoassay techniques such as: WB, IHC, IHC-P.
See all MXD4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2858
Antibody Isotype
IgG2b
Application
WB, IHC, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human MXD4 (NP_006445) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MXD4
Introduction
This gene is a member of the MAD gene family. The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Entrez Gene ID
10608
UniProt ID
Q14582
Alternative Names
MAX Dimerization Protein 4; Max-Interacting Transcriptional Repressor MAD4; Class C Basic Helix-Loop-Helix Protein 12; Max-Associated Protein 4; Max Dimerizer 4; BHLHc12
Function
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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