NAIP5

NAIP5 is a protein coding gene.

Full Name

NLR family, apoptosis inhibitory protein 5

Function

Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158).

Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158).

The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158).

May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity).

Biological Process

Defense response to bacterium Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Detection of bacterium Source: UniProtKB
Entry of bacterium into host cell Source: MGI
Inflammatory response Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of JNK cascade Source: MGI
Pyroptosis Source: UniProtKB
Regulation of apoptotic process Source: MGI

Cellular Location

IPAF inflammasome complex