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NEIL2

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

Full Name

Nei Like DNA Glycosylase 2

Function

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

Biological Process

Base-excision repair Source: GO_Central
Depyrimidination Source: Reactome

Cellular Location

Nucleus

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Anti-NEIL2 antibodies

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Mouse Anti-NEIL2 Recombinant Antibody (1B7) (CBMAB-N1908-WJ)

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Target: NEIL2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1B7

Application*: E, WB

NEIL2 Matched Antibody Pair (787) (APMAB-787LY)

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Target: NEIL2

Specificity: Human

Rabbit Anti-NEIL2 Recombinant Antibody (CBWJN-1314) (CBMAB-N1910-WJ)

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Target: NEIL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJN-1314

Application*: WB, IP, F

Mouse Anti-NEIL2 Recombinant Antibody (CBWJN-1313) (CBMAB-N1909-WJ)

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Target: NEIL2

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: CBWJN-1313

Application*: WB

Mouse Anti-NEIL2 Recombinant Antibody (CBWJN-0312) (CBMAB-N0240-WJ)

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Target: NEIL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0312

Application*: DB, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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