NEIL2

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Full Name
Nei Like DNA Glycosylase 2
Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Biological Process
Base-excision repair Source: GO_Central
Depyrimidination Source: Reactome
Cellular Location
Nucleus
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Anti-NEIL2 antibodies

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Mouse Anti-NEIL2 Recombinant Antibody (1B7) (CBMAB-N1908-WJ)

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Target: NEIL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B7
Application*: E, WB
Datasheet SDS

NEIL2 Matched Antibody Pair (787) (APMAB-787LY)

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Target: NEIL2
Specificity: Human
Datasheet SDS

Rabbit Anti-NEIL2 Recombinant Antibody (CBWJN-1314) (CBMAB-N1910-WJ)

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Target: NEIL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1314
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-NEIL2 Recombinant Antibody (CBWJN-1313) (CBMAB-N1909-WJ)

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Target: NEIL2
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBWJN-1313
Application*: WB
Datasheet SDS

Mouse Anti-NEIL2 Recombinant Antibody (CBWJN-0312) (CBMAB-N0240-WJ)

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Target: NEIL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0312
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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