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NEIL2 Matched Antibody Pair (787) (APMAB-787LY)

This antibody pair set can be used for detecting and quantifying protein level of human NEIL2.
See all NEIL2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NEIL2 polyclonal antibody, 100 ug
Detection Antibody
Anti-NEIL2 Mouse polyclonal antibody, 40 ul
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Alternative Names
Nei Like DNA Glycosylase 2; DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil2; DNA Glycosylase/AP Lyase Neil2; Nei-Like Protein 2; Nei Homolog 2; NEH2; Nei Endonuclease VIII-Like 2 (E. Coli); Nei Endonuclease VIII-Like 2;
Entrez Gene ID
252969
UniProt ID
Q969S2

Tapryal, N., Chakraborty, A., Saha, K., Islam, A., Pan, L., Hosoki, K., ... & Hazra, T. K. (2023). The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection. Nature Communications, 14(1), 8169.

Zhdanova, P. V., Ishchenko, A. A., Chernonosov, A. A., Zharkov, D. O., & Koval, V. V. (2022). Dynamics and conformational changes in human NEIL2 DNA glycosylase analyzed by hydrogen/deuterium exchange mass spectrometry. Journal of Molecular Biology, 434(2), 167334.

Hanna, B. M., Michel, M., Helleday, T., & Mortusewicz, O. (2021). NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487. International Journal of Molecular Sciences, 22(9), 4542.

Sarker, A. H., Cooper, P. K., & Hazra, T. K. (2021). DNA glycosylase NEIL2 functions in multiple cellular processes. Progress in biophysics and molecular biology, 164, 72-80.

Eckenroth, B. E., Cao, V. B., Averill, A. M., Dragon, J. A., & Doublié, S. (2021). Unique structural features of mammalian NEIL2 DNA glycosylase prime its activity for diverse DNA substrates and environments. Structure, 29(1), 29-42.

Tapryal, N., Shahabi, S., Chakraborty, A., Hosoki, K., Wakamiya, M., Sarkar, G., ... & Hazra, T. K. (2021). Intrapulmonary administration of purified NEIL2 abrogates NF-κB–mediated inflammation. Journal of Biological Chemistry, 296.

Cumova, A., Vymetalkova, V., Opattova, A., Bouskova, V., Pardini, B., Kopeckova, K., ... & Vodicka, P. (2021). Genetic variations in 3′ UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response. Mutagenesis, 36(4), 269-279.

Sayed, I. M., Sahan, A. Z., Venkova, T., Chakraborty, A., Mukhopadhyay, D., Bimczok, D., ... & Das, S. (2020). Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells. Journal of Biological Chemistry, 295(32), 11082-11098.

Sayed, I. M., Chakraborty, A., El-Hafeez, A., Ali, A., Sharma, A., Sahan, A. Z., ... & Das, S. (2020). The DNA glycosylase NEIL2 suppresses fusobacterium-infection-induced inflammation and DNA damage in colonic epithelial cells. Cells, 9(9), 1980.

Han, D., Schomacher, L., Schüle, K. M., Mallick, M., Musheev, M. U., Karaulanov, E., ... & Niehrs, C. (2019). NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. elife, 8, e49044.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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