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NEUROG3

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Full Name
Neurogenin 3
Function
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
Biological Process
Central nervous system development Source: ProtInc
Endocrine pancreas development Source: InterPro
Epithelial cell differentiation Source: Ensembl
Forebrain development Source: Ensembl
Hindbrain development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Nervous system development Source: ProtInc
Neuron differentiation Source: GO_Central
Peripheral nervous system development Source: ProtInc
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of dendrite morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spinal cord development Source: Ensembl
Transdifferentiation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Diarrhea 4, malabsorptive, congenital (DIAR4):
A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.

Anti-NEUROG3 antibodies

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Human
Clone: F25A1B3
Application*: CI, P, IF, WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A6
Application*: IP, M
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5A8
Application*: WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B5
Application*: IC, IH, P, WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GF1
Application*: E
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: CBWJN-0474
Application*: WB, IF
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G2
Application*: WB, E
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B7
Application*: E, IF, IP, WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G9
Application*: E, WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0135
Application*: E, WB
Target: NEUROG3
Host: Mouse
Specificity: Human
Clone: 4E9
Application*: E, IF, IP, WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1346
Application*: WB
Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E3
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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