NEUROG3

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Full Name
Neurogenin 3
Function
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
Biological Process
Central nervous system development Source: ProtInc
Endocrine pancreas development Source: InterPro
Epithelial cell differentiation Source: Ensembl
Forebrain development Source: Ensembl
Hindbrain development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Nervous system development Source: ProtInc
Neuron differentiation Source: GO_Central
Peripheral nervous system development Source: ProtInc
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of dendrite morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spinal cord development Source: Ensembl
Transdifferentiation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Diarrhea 4, malabsorptive, congenital (DIAR4):
A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
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Anti-NEUROG3 antibodies

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Mouse Anti-NEUROG3 Antibody (F25A1B3) (CBMAB-1453CQ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Human
Clone: F25A1B3
Application*: CI, P, IF, WB
Datasheet SDS

Mouse Anti-NEUROG3 Antibody (2A6) (CBMAB-0714-YC)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A6
Application*: IP, M
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (CBT943) (V2LY-0625-LY3162)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT943
Application*: WB, E
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (CBT2661) (V2LY-0625-LY2295)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2661
Application*: WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (5A8) (CBMAB-N2413-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5A8
Application*: WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (3B5) (CBMAB-N2412-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B5
Application*: IC, IH, P, WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (GF1) (CBMAB-N2102-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GF1
Application*: E
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (CBWJN-0474) (CBMAB-N2101-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: CBWJN-0474
Application*: WB, IF
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (6G2) (CBMAB-N2100-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G2
Application*: WB, E
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (4B7) (CBMAB-N2094-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B7
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (2G9) (CBMAB-N2088-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G9
Application*: E, WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (CBWJN-0135) (CBMAB-N2087-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0135
Application*: E, WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (4E9) (CBMAB-N2086-WJ)

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Target: NEUROG3
Host: Mouse
Specificity: Human
Clone: 4E9
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (CBWJN-1346) (CBMAB-N2085-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1346
Application*: WB
Datasheet SDS

Mouse Anti-NEUROG3 Recombinant Antibody (1E3) (CBMAB-N2084-WJ)

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Target: NEUROG3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E3
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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