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NGB

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

Full Name

Neuroglobin

Function

Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Oxygen transport1 PublicationNAS:UniProtKB

Cellular Location

Perikaryon
Cytoplasm
Mitochondrion

PTM

A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.

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Anti-NGB antibodies

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Rat Ngb ELISA Kit (V2LY-0626-LY902)

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Target: Ngb

Sensitivity: 0.0024 ng/mL

Detection Range: 0.005-1 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Rat

Assay Type: Sandwich

Reactivity: Rat

Human NGB ELISA Kit (V2LY-0626-LY1563)

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Target: NGB

Sensitivity: 0.26 ng/mL

Detection Range: 0.5-200 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962)

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Target: NGB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBT4696

Application*: WB, F

NGB Matched Antibody Pair (798) (APMAB-798LY)

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Target: NGB

Specificity: Human

Mouse Anti-NGB Recombinant Antibody (2B5-A7) (CBMAB-A5954-LY)

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Target: NGB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2B5-A7

Application*: WB, E

Mouse Anti-NGB Recombinant Antibody (CBWJN-0279) (CBMAB-N2339-WJ)

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Target: NGB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0279

Application*: E, WB

Mouse Anti-NGB Recombinant Antibody (13C8) (CBMAB-N2338-WJ)

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Target: NGB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13C8

Application*: IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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