NGB

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Full Name
Neuroglobin
Function
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Oxygen transport1 PublicationNAS:UniProtKB
Cellular Location
Perikaryon
Cytoplasm
Mitochondrion
PTM
A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.
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Anti-NGB antibodies

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Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962)

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Target: NGB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBT4696
Application*: WB, F
Datasheet SDS

NGB Matched Antibody Pair (798) (APMAB-798LY)

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Target: NGB
Specificity: Human
Datasheet SDS

Mouse Anti-NGB Recombinant Antibody (2B5-A7) (CBMAB-A5954-LY)

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Target: NGB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B5-A7
Application*: WB, E
Datasheet SDS

Mouse Anti-NGB Recombinant Antibody (CBWJN-0279) (CBMAB-N2339-WJ)

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Target: NGB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0279
Application*: E, WB
Datasheet SDS

Mouse Anti-NGB Recombinant Antibody (13C8) (CBMAB-N2338-WJ)

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Target: NGB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13C8
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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