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Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962)


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Tested Data
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in ELISA
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in ELISA
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in WB
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in WB
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in WB
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in WB
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in WB
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in WB
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in FC
Mouse Anti-NGB Recombinant Antibody (CBT4696) (V2LY-0625-LY1962) in FC

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBT4696
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human NGB(AA: full 1-151) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
58157
UniProt ID
Q9NPG2
Function
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Oxygen transport1 PublicationNAS:UniProtKB
Cellular Location
Perikaryon
Cytoplasm
Mitochondrion
PTM
A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.
More Infomation

Xiang, Q., Zhou, D., Xiang, X., Le, X., Deng, C., Sun, R., ... & Xiang, T. (2023). Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer. Clinical Epigenetics, 15(1), 57.

Li, C. Y., Jiang, H. F., Li, L., Lai, X. J., Liu, Q. R., Yu, S. B., ... & Chen, X. Q. (2023). Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?. Neuroscience Bulletin, 1-16.

Exertier, C., Montemiglio, L. C., Freda, I., Gugole, E., Parisi, G., Savino, C., & Vallone, B. (2022). Neuroglobin, clues to function and mechanism. Molecular Aspects of Medicine, 84, 101055.

Gøtzsche, C. R., Woldbye, D. P., Hundahl, C. A., & Hay‐Schmidt, A. (2022). Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice. Journal of Neuroscience Research, 100(10), 1921-1932.

Ciccone, L., Nencetti, S., Socci, S., & Orlandini, E. (2021). Neuroglobin and neuroprotection: The role of natural and synthetic compounds in neuroglobin pharmacological induction. Neural regeneration research, 16(12), 2353.

De Simone, G., Sbardella, D., Oddone, F., Pesce, A., Coletta, M., & Ascenzi, P. (2021). Structural and (pseudo-) enzymatic properties of neuroglobin: its possible role in neuroprotection. Cells, 10(12), 3366.

Solar Fernandez, V., Fiocchetti, M., Cipolletti, M., Segatto, M., Cercola, P., Massari, A., ... & Marino, M. (2021). Neuroglobin: A new possible marker of estrogen-responsive breast cancer. Cells, 10(8), 1986.

Ding, C. Y., Kang, D. Z., Wang, Z. L., Lin, Y. X., Jiang, C. Z., Yu, L. H., ... & Gu, J. J. (2019). Serum Ngb (neuroglobin) is associated with brain metabolism and functional outcome of aneurysmal subarachnoid hemorrhage. Stroke, 50(7), 1887-1890.

Van Acker, Z. P., Luyckx, E., & Dewilde, S. (2019). Neuroglobin expression in the brain: a story of tissue homeostasis preservation. Molecular neurobiology, 56, 2101-2122.

Luyckx, E., Van Acker, Z. P., Ponsaerts, P., & Dewilde, S. (2019). Neuroglobin expression models as a tool to study its function. Oxidative medicine and cellular longevity, 2019.

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For research use only. Not intended for any clinical use.

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