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Mouse Anti-NGB Recombinant Antibody (13C8) (CBMAB-N2338-WJ)

This product is a Mouse antibody that recognizes NGB. The antibody 13C8 can be used for immunoassay techniques such as: IHC.
See all NGB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13C8
Antibody Isotype
IgG1
Application
IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
50mM PBS, pH 7.2, 100mM NaCl
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuroglobin
Introduction
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Entrez Gene ID
58157
UniProt ID
Q9NPG2
Alternative Names
Neuroglobin;
Function
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Oxygen transport1 PublicationNAS:UniProtKB
Cellular Location
Perikaryon
Cytoplasm
Mitochondrion
PTM
A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.

Xiang, Q., Zhou, D., Xiang, X., Le, X., Deng, C., Sun, R., ... & Xiang, T. (2023). Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer. Clinical Epigenetics, 15(1), 57.

Li, C. Y., Jiang, H. F., Li, L., Lai, X. J., Liu, Q. R., Yu, S. B., ... & Chen, X. Q. (2023). Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?. Neuroscience Bulletin, 1-16.

Exertier, C., Montemiglio, L. C., Freda, I., Gugole, E., Parisi, G., Savino, C., & Vallone, B. (2022). Neuroglobin, clues to function and mechanism. Molecular Aspects of Medicine, 84, 101055.

Gøtzsche, C. R., Woldbye, D. P., Hundahl, C. A., & Hay‐Schmidt, A. (2022). Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice. Journal of Neuroscience Research, 100(10), 1921-1932.

Ciccone, L., Nencetti, S., Socci, S., & Orlandini, E. (2021). Neuroglobin and neuroprotection: The role of natural and synthetic compounds in neuroglobin pharmacological induction. Neural regeneration research, 16(12), 2353.

De Simone, G., Sbardella, D., Oddone, F., Pesce, A., Coletta, M., & Ascenzi, P. (2021). Structural and (pseudo-) enzymatic properties of neuroglobin: its possible role in neuroprotection. Cells, 10(12), 3366.

Solar Fernandez, V., Fiocchetti, M., Cipolletti, M., Segatto, M., Cercola, P., Massari, A., ... & Marino, M. (2021). Neuroglobin: A new possible marker of estrogen-responsive breast cancer. Cells, 10(8), 1986.

Ding, C. Y., Kang, D. Z., Wang, Z. L., Lin, Y. X., Jiang, C. Z., Yu, L. H., ... & Gu, J. J. (2019). Serum Ngb (neuroglobin) is associated with brain metabolism and functional outcome of aneurysmal subarachnoid hemorrhage. Stroke, 50(7), 1887-1890.

Van Acker, Z. P., Luyckx, E., & Dewilde, S. (2019). Neuroglobin expression in the brain: a story of tissue homeostasis preservation. Molecular neurobiology, 56, 2101-2122.

Luyckx, E., Van Acker, Z. P., Ponsaerts, P., & Dewilde, S. (2019). Neuroglobin expression models as a tool to study its function. Oxidative medicine and cellular longevity, 2019.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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