NGDN

Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).

Full Name

neuroguidin, EIF4E binding protein

Function

Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Biological Process

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIBA:GO_Central
Regulation of translationIEA:UniProtKB-KW

Cellular Location

Nucleus
Nucleus, nucleolus
Chromosome, centromere
Cytoplasm
Cell projection, axon
Cell projection, dendrite
Cell projection, filopodium
Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity).
Translocated from nucleolus to nuclear foci in response to UV damage.

Anti-NGDN antibodies

Mouse Anti-NGDN Recombinant Antibody (8B5) (CBMAB-N2344-WJ)

Datasheet

SDS

Target: NGDN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8B5

Application*: WB

Mouse Anti-NGDN Recombinant Antibody (1H4) (CBMAB-N2343-WJ)

Datasheet

SDS

Target: NGDN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1H4

Application*: WB, IH

Mouse Anti-NGDN Recombinant Antibody (1B8) (CBMAB-N2342-WJ)

Datasheet

SDS

Target: NGDN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B8

Application*: WB, IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)