NLRC3

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants.

Full Name

NLR Family CARD Domain Containing 3

Function

Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106).
Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753).
May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753).
Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity).
May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106).
Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).

Biological Process

I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cytokine production involved in inflammatory responseISS:UniProtKB
Negative regulation of epithelial cell proliferationISS:UniProtKB
Negative regulation of fibroblast proliferationISS:UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:MGI
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of innate immune responseISS:UniProtKB
Negative regulation of interferon-alpha productionISS:UniProtKB
Negative regulation of interferon-beta productionISS:UniProtKB
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of NLRP3 inflammasome complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:CACAO
T cell activationManual Assertion Based On ExperimentIEP:UniProtKB

Cellular Location

Cytoplasm