NPR3

This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Full Name
Natriuretic Peptide Receptor 3
Function
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of adenylate cyclase activityIEA:Ensembl
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Negative regulation of smooth muscle cell proliferationIEA:Ensembl
Osteoclast proliferationISS:UniProtKB
Pancreatic juice secretionIEA:Ensembl
Phosphatidylinositol-mediated signalingIEA:Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Positive regulation of nitric-oxide synthase activityISS:BHF-UCL
Positive regulation of urine volumeISS:UniProtKB
Regulation of blood pressureISS:UniProtKB
Regulation of osteoblast proliferationISS:UniProtKB
Skeletal system developmentISS:UniProtKB
VasodilationIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 27-481
Helical: 482-504
Cytoplasmic: 505-541
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Anti-NPR3 antibodies

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Mouse Anti-NPR3 Recombinant Antibody (B-9) (CBMAB-N3256-WJ)

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Target: NPR3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: B-9
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (11A6) (CBMAB-N3245-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11A6
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (E-5) (CBMAB-N3257-WJ)

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Target: NPR3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: E-5
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (4H1) (CBMAB-N3255-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H1
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (4C3) (CBMAB-N3254-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4C3
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (4A1) (CBMAB-N3253-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 4A1
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (2G2) (CBMAB-N3252-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2G2
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (2B12) (CBMAB-N3251-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B12
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (CBWJN-0276) (CBMAB-N3250-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0276
Application*: E, WB
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (11B6) (CBMAB-N3247-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11B6
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (11B5) (CBMAB-N3246-WJ)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11B5
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NPR3 Recombinant Antibody (CBLG1-2392) (CBMAB-G6402-LY)

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Target: NPR3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-2392
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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