NSG1

Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).

Full Name

neuron specific gene family member 1

Function

Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity).
Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity).
In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).

Biological Process

Amyloid precursor protein metabolic processISS:UniProtKB
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Clathrin coat assemblyManual Assertion Based On ExperimentIBA:GO_Central
Dopamine receptor signaling pathwayIEA:InterPro
Endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter receptor cycleISS:UniProtKB
Neurotransmitter receptor transport, endosome to postsynaptic membraneIEA:Ensembl
Positive regulation of receptor recyclingIEA:Ensembl
Postsynaptic neurotransmitter receptor cycleISS:UniProtKB
Receptor recyclingISS:UniProtKB
Regulation of long-term synaptic potentiationISS:UniProtKB
Spontaneous synaptic transmissionISS:UniProtKB
Vesicle-mediated transport in synapseIEA:Ensembl

Cellular Location

Membrane
Golgi apparatus, trans-Golgi network membrane
Endosome membrane
Cell projection, dendrite
Early endosome membrane
Late endosome membrane
Lysosome lumen
Recycling endosome membrane
Cytoplasmic vesicle membrane
Golgi apparatus, Golgi stack membrane
Endosome, multivesicular body membrane
Endoplasmic reticulum membrane
Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity).
Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942).
Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity).

Topology

Cytoplasmic: 1-82
Helical: 83-103
Lumenal: 104-185