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Mouse Anti-NSG1 Recombinant Antibody (1C3) (CBMAB-A2065-LY)

The product is antibody recognizes D4S234E. The antibody 1C3 immunoassay techniques such as: WB, ELISA.
See all NSG1 antibodies
Published Data
Fig.1 U2OS and SaOS-2 cells were treated with ADR for indicated times and then analyzed by Western blotting.
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Fig.2 D4S234E induces apoptosis.
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Fig.3 Endogenous D4S234E localizes in the ER and accumulates in response to DNA damage.
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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
1C3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
D4S234E (AAH01745, 1 a.a. ~ 185 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
neuron specific gene family member 1
Entrez Gene ID
Human27065
Rat25247
UniProt ID
HumanP42857
RatP02683
Alternative Names
D4S234; NEEP21; NSG1; P21
Function
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity).
Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity).
In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).
Biological Process
Amyloid precursor protein metabolic processISS:UniProtKB
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Clathrin coat assemblyManual Assertion Based On ExperimentIBA:GO_Central
Dopamine receptor signaling pathwayIEA:InterPro
Endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter receptor cycleISS:UniProtKB
Neurotransmitter receptor transport, endosome to postsynaptic membraneIEA:Ensembl
Positive regulation of receptor recyclingIEA:Ensembl
Postsynaptic neurotransmitter receptor cycleISS:UniProtKB
Receptor recyclingISS:UniProtKB
Regulation of long-term synaptic potentiationISS:UniProtKB
Spontaneous synaptic transmissionISS:UniProtKB
Vesicle-mediated transport in synapseIEA:Ensembl
Cellular Location
Membrane
Golgi apparatus, trans-Golgi network membrane
Endosome membrane
Cell projection, dendrite
Early endosome membrane
Late endosome membrane
Lysosome lumen
Recycling endosome membrane
Cytoplasmic vesicle membrane
Golgi apparatus, Golgi stack membrane
Endosome, multivesicular body membrane
Endoplasmic reticulum membrane
Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity).
Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942).
Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity).
Topology
Cytoplasmic: 1-82
Helical: 83-103
Lumenal: 104-185
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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