NTMT1

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

Full Name

N-Terminal Xaa-Pro-Lys N-Methyltransferase 1

Function

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352).
Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Biological Process

Chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-alanine methylationManual Assertion Based On ExperimentIBA:GO_Central
N-terminal peptidyl-alanine trimethylationIEA:Ensembl
N-terminal peptidyl-glycine methylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-proline dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-proline methylationManual Assertion Based On ExperimentIBA:GO_Central
N-terminal peptidyl-serine dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-serine methylationManual Assertion Based On ExperimentIBA:GO_Central
N-terminal peptidyl-serine trimethylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal protein amino acid methylationManual Assertion Based On ExperimentIBA:GO_Central
Spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Predominantly nuclear (PubMed:24090352).