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Rabbit Anti-NTMT1 Recombinant Antibody (D9D6P) (CBMAB-N3604-WJ)

This product is a Rabbit antibody that recognizes NTMT1. The antibody D9D6P can be used for immunoassay techniques such as: WB.
See all NTMT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D9D6P
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-Terminal Xaa-Pro-Lys N-Methyltransferase 1
Introduction
NTMT1 (N-Terminal Xaa-Pro-Lys N-Methyltransferase 1) is a Protein Coding gene. Among its related pathways are DNA Damage. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and O-methyltransferase activity. An important paralog of this gene is METTL11B.
Entrez Gene ID
Human28989
Mouse66617
Rat362103
Monkey716763
UniProt ID
HumanQ9BV86
MouseQ8R2U4
RatQ5BJX0
MonkeyF7HMB4
Alternative Names
AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1, NTM1A
Function
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352).
Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Biological Process
Chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-alanine methylationManual Assertion Based On ExperimentIBA:GO_Central
N-terminal peptidyl-alanine trimethylationIEA:Ensembl
N-terminal peptidyl-glycine methylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-proline dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-proline methylationManual Assertion Based On ExperimentIBA:GO_Central
N-terminal peptidyl-serine dimethylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal peptidyl-serine methylationManual Assertion Based On ExperimentIBA:GO_Central
N-terminal peptidyl-serine trimethylationManual Assertion Based On ExperimentIDA:UniProtKB
N-terminal protein amino acid methylationManual Assertion Based On ExperimentIBA:GO_Central
Spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Predominantly nuclear (PubMed:24090352).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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