NUP50

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

nucleoporin 50kDa

Function

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008).
Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008).
Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity).
This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity).

Biological Process

mRNA transportIEA:UniProtKB-KW
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nuclear pore complex
Nucleus membrane
Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity).
Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065).
Associates with the newly formed nuclear membrane during telophase (PubMed:12802065).
In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity).