PANK1

This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

Pantothenate Kinase 1

Isoform 1
Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.

Coenzyme A biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Isoform 1
Nucleus
Nucleus, nucleolus
Isoform 2
Cytoplasm, cytosol
Cytoplasmic vesicle, clathrin-coated vesicle
Recycling endosome