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Rabbit Anti-PANK1 Recombinant Antibody (CBYC-P155) (CBMAB-P0723-YC)

Provided herein is a Rabbit monoclonal antibody against Human Pantothenate Kinase 1. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PANK1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBYC-P155
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pantothenate Kinase 1
Introduction
PANK1 is a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636).
Entrez Gene ID
Human53354
Monkey696041
UniProt ID
HumanQ8TE04
MonkeyF7GV14
Alternative Names
Pantothenate Kinase 1; Pantothenic Acid Kinase 1; EC 2.7.1.33; PANK; Pantothenate Kinase; HPanK1; HPanK;
Function
Isoform 1
Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Biological Process
Coenzyme A biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Isoform 1
Nucleus
Nucleus, nucleolus
Isoform 2
Cytoplasm, cytosol
Cytoplasmic vesicle, clathrin-coated vesicle
Recycling endosome

Zhao, Z., Xu, X., Ma, S., & Li, L. (2024). Expression and Prognostic Role of PANK1 in Glioma. Combinatorial Chemistry & High Throughput Screening, 27(5), 715-724.

Liu, Q., Li, Q., Zhang, R., Wang, H., Li, Y., Liu, Z., ... & Wang, L. (2022). circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson’s disease. Cell Death & Disease, 13(5), 477.

Wang, B., Liu, B., Luo, Q., Sun, D., Li, H., Zhang, J., ... & Chen, Y. (2022). PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: A retrospective prognostic study based on the TCGA database. Translational Cancer Research, 11(7), 2321.

Audam, T. N., Howard, C. M., Garrett, L. F., Zheng, Y. W., Bradley, J. A., Brittian, K. R., ... & Jones, S. P. (2021). Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H784-H797.

Audam, T. N., Howard, C. M., Garrett, L. F., Zheng, Y. W., Bradley, J. A., Brittian, K. R., ... & Jones, S. P. (2021). Integrative Cardiovascular Physiology and Pathophysiology: Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H784.

Ma, B., & Wang, P. (2021). PANK1 is a Prognostic Biomarker Associated with Immune Infiltration of Clear Cell Renal Carcinoma. Available at SSRN 3977791.

Audam, T. N. (2021). Impact of PANK1 deletion on mitochondrial acetylation and cardiac function during pressure overload.

Yang, L., Zhang, B., Wang, X., Liu, Z., Li, J., Zhang, S., ... & Chen, L. (2020). P53/PANK1/miR‐107 signalling pathway spans the gap between metabolic reprogramming and insulin resistance induced by high‐fat diet. Journal of cellular and molecular medicine, 24(6), 3611-3624.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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