PATL1

PATL1 has ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues.

Full Name

PAT1 Homolog 1, Processing Body MRNA Decay Factor

Function

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
(Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).

Biological Process

Deadenylation-dependent decapping of nuclear-transcribed mRNAManual Assertion Based On ExperimentIDA:UniProtKB
P-body assemblyManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, P-body
Nucleus
Nucleus, PML body
Nucleus speckle
Predominantly cytoplasmic (PubMed:22090346).
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:22090346).
Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (PubMed:22090346).