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Rabbit Anti-PATL1 Recombinant Antibody (D8P1B) (CBMAB-P0845-YC)

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Basic Information

Host Animal
Rabbit
Clone
D8P1B
Application
WB
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
PAT1 Homolog 1, Processing Body MRNA Decay Factor
Introduction
PATL1 has ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues.
Entrez Gene ID
Human219988
Mouse225929
Rat361736
Monkey699207
UniProt ID
HumanQ86TB9
MouseQ3TC46
RatB5DF93
MonkeyF7HUF8
Alternative Names
PAT1 Homolog 1, Processing Body MRNA Decay Factor; Protein PAT1 Homolog B; PAT1-Like Protein 1; HPat1b; Pat1b; Protein Associated With Topoisomerase II Homolog 1 (Yeast); Protein Associated With Topoisomerase II Homolog 1; Protein PAT1 Homolog 1;
Function
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
(Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).
Biological Process
Deadenylation-dependent decapping of nuclear-transcribed mRNAManual Assertion Based On ExperimentIDA:UniProtKB
P-body assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, P-body
Nucleus
Nucleus, PML body
Nucleus speckle
Predominantly cytoplasmic (PubMed:22090346).
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:22090346).
Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (PubMed:22090346).

Yao, L., Ruan, M. Y., Ye, S. W., & Cai, S. Q. (2023). DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K+ channels. Proceedings of the National Academy of Sciences, 120(2), e2206146120.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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