PCDH11X

PCDH11X belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia.

Full Name

Protocadherin 11 X-Linked

Function

Potential calcium-dependent cell-adhesion protein.

Biological Process

Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 24-812
Helical: 813-833
Cytoplasmic: 834-1347