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PCSK2

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq]

Full Name

proprotein convertase subtilisin/kexin type 2

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Biological Process

Enkephalin processingISS:BHF-UCL
Insulin processingManual Assertion Based On ExperimentIDA:BHF-UCL
Islet amyloid polypeptide processingISS:BHF-UCL
Nervous system developmentIEA:Ensembl
Peptide hormone processingManual Assertion Based On ExperimentIDA:UniProtKB
Protein autoprocessingIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cytoplasmic vesicle, secretory vesicle
Secreted
Localized in the secretion granules.

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Anti-PCSK2 antibodies

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Rabbit Anti-PCSK2 Recombinant Antibody (D1E1S) (CBMAB-P1099-YC)

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Target: PCSK2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Frog, Cattle, Horse

Clone: D1E1S

Application*: WB, IP, P, IF, IF

Mouse Anti-PCSK2 Recombinant Antibody (CBYC-P226) (CBMAB-P1098-YC)

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Target: PCSK2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYC-P226

Application*: WB, IP, IC

Mouse Anti-PCSK2 Recombinant Antibody (3H4) (CBMAB-P1097-YC)

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Target: PCSK2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3H4

Application*: E, WB

Mouse Anti-PCSK2 Recombinant Antibody (11n157) (CBMAB-P1096-YC)

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Target: PCSK2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 11n157

Application*: IP, WB

Mouse Anti-PCSK2 Recombinant Antibody (CBXF-3284) (CBMAB-F3978-CQ)

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Target: PCSK2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBXF-3284

Application*: IC, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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