PCSK2

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq]

proprotein convertase subtilisin/kexin type 2

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Enkephalin processingISS:BHF-UCL
Insulin processingManual Assertion Based On ExperimentIDA:BHF-UCL
Islet amyloid polypeptide processingISS:BHF-UCL
Nervous system developmentIEA:Ensembl
Peptide hormone processingManual Assertion Based On ExperimentIDA:UniProtKB
Protein autoprocessingIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentIDA:BHF-UCL

Cytoplasmic vesicle, secretory vesicle
Secreted
Localized in the secretion granules.