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Mouse Anti-PCSK2 Recombinant Antibody (3H4) (CBMAB-P1097-YC)

Provided herein is a Mouse monoclonal antibody against Human Proprotein Convertase Subtilisin/Kexin Type 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PCSK2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proprotein convertase subtilisin/kexin type 2
Introduction
PCSK2 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression.
Entrez Gene ID
5126
UniProt ID
P16519
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 2; KEX2-Like Endoprotease 2; Neuroendocrine Convertase 2; Prohormone Convertase 2; EC 3.4.21.94; NEC 2; NEC2;
Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
Biological Process
Enkephalin processingISS:BHF-UCL
Insulin processingManual Assertion Based On ExperimentIDA:BHF-UCL
Islet amyloid polypeptide processingISS:BHF-UCL
Nervous system developmentIEA:Ensembl
Peptide hormone processingManual Assertion Based On ExperimentIDA:UniProtKB
Protein autoprocessingIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cytoplasmic vesicle, secretory vesicle
Secreted
Localized in the secretion granules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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