Rabbit Anti-PCSK2 Recombinant Antibody (D1E1S) (CBMAB-P1099-YC)

Name: Rabbit Anti-PCSK2 Recombinant Antibody (D1E1S)
SKU: CBMAB-P1099-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D1E1S

Application

WB, IP, IHC-P, IF, IF

Specificity

Human, Mouse, Rat, Frog, Cattle, Horse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

proprotein convertase subtilisin/kexin type 2

Introduction

PCSK2 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression.

Entrez Gene ID

Human	5126
Mouse	18549
Rat	25121
Frog	100036632
Cattle	281968
Horse	100050755

UniProt ID

Human	P16519
Mouse	P21661
Rat	P28841
Frog	A0JP87
Cattle	Q9GLR0
Horse	F6W2D5

Alternative Names

Proprotein Convertase Subtilisin/Kexin Type 2; KEX2-Like Endoprotease 2; Neuroendocrine Convertase 2; Prohormone Convertase 2; EC 3.4.21.94; NEC 2; NEC2;

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Biological Process

Enkephalin processingISS:BHF-UCL
Insulin processingManual Assertion Based On ExperimentIDA:BHF-UCL
Islet amyloid polypeptide processingISS:BHF-UCL
Nervous system developmentIEA:Ensembl
Peptide hormone processingManual Assertion Based On ExperimentIDA:UniProtKB
Protein autoprocessingIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cytoplasmic vesicle, secretory vesicle
Secreted
Localized in the secretion granules.

Basu, J., Mukherjee, R., Sahu, P., Datta, C., Chowdhury, S., Mandal, D., & Ghosh, A. (2024). Association of common variants of TCF7L2 and PCSK2 with gestational diabetes mellitus in West Bengal, India. Nucleosides, Nucleotides & Nucleic Acids, 43(3), 185-202.

Wang, B., Fang, W., Qin, D., He, Q., & Lan, C. (2023). Susceptibility of PCSK2 Polymorphism to Hirschsprung Disease in Southern Chinese Children. Clinical and Experimental Gastroenterology, 59-64.

Zanesco, A. M., Mendes, N. F., Engel, D. F., Gaspar, R. S., Sidarta-Oliveira, D., Donato Jr, J., & Velloso, L. A. (2022). Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2. Cells, 11(13), 1996.

Callon, D., Guedra, A., Lebreil, A. L., Heng, L., Bouland, N., Fornès, P., ... & Andreoletti, L. (2022). Replication Activities of Major 5′ Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells. Viruses, 14(12), 2781.

Taylor, A., Chen, Y. C., Pasula, D., Luciani, D. S., & Verchere, B. (2021). 123-OR: Deletion of Both Pcsk1 And Pcsk2 in Beta Cells: Lack of Mature Insulin Drives Beta-Cell Expansion and Dysfunction, but Not Severe Diabetes in Mice. Diabetes, 70(Supplement_1).

Remes, S. M., Leijon, H., Vesterinen, T., Louhimo, J., Pulkkinen, V., Ezer, S., ... & Arola, J. (2020). PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma–paraganglioma origin. Apmis, 128(11), 563-572.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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