PDCD2

PDCD2 is a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.

Full Name

Programmed Cell Death 2

Function

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of hematopoietic stem cell proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of hematopoietic progenitor cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus

PTM

Ubiquitinated by PRKN, promoting proteasomal degradation.