PDIA4
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]
Full Name
Protein Disulfide Isomerase Family A Member 3
Biological Process
Chaperone-mediated protein foldingISS:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
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Anti-PDIA4 antibodies
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CompareTarget: PDIA4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H3
Application*: WB, E
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B6
Application*: WB, F
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E2
Application*: F, WB
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E11
Application*: IF, WB
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Monkey
Clone: 2C11
Application*: WB, IH
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: 2B9
Application*: WB, IH
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 2A11
Application*: IH, WB
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D5F3
Application*: E, WB, IH, IF
Target: PDIA4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1585
Application*: IF
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: CBFYE-1584
Application*: WB, IH, P
Target: PDIA4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYE-1583
Application*: WB, IF, F
Target: PDIA4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1582
Application*: WB, IP
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1581
Application*: WB
Target: PDIA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 3/ERp72
Application*: WB, IF
Target: PDIA4
Sensitivity: 0.0076 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Pdia4
Sensitivity: 0.058 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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