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PDIA6

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM

Full Name

protein disulfide isomerase family A, member 6

Function

May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115).
Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390).
May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390).
Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Biological Process

Protein foldingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Endoplasmic reticulum lumen
Cell membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).

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Anti-PDIA6 antibodies

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Rabbit Anti-PDIA6 Recombinant Antibody (CBYC-P267) (CBMAB-P1308-YC)

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Target: PDIA6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P267

Application*: IC, IF

Mouse Anti-PDIA6 Recombinant Antibody (3B4) (CBMAB-P1307-YC)

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Target: PDIA6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3B4

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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