Mouse Anti-PDIA6 Recombinant Antibody (3B4) (CBMAB-P1307-YC)

Name: Mouse Anti-PDIA6 Recombinant Antibody (3B4)
SKU: CBMAB-P1307-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3B4

Application

ELISA, WB

Immunogen

PDIA6 (AAH01312, 1-440 aa) full length recombinant protein with GST tag. Immunogen sequence: MALLVLGLVS CTFFLAVNGL YSSSDDVIEL TPSNFNREVI QSDSLWLVEF YAPWCGHCQR LTPEWKKAAT ALKDVVKVGA VDADKHHSLG GQYGVQGFPT IKIFGSNKNR PEDYQGGRTG EAIVDAALSA LRQLVKDRLG GRSGGYSSGK QGRSDSSSKK DVIELTDDSF DRNVLDSEDV WMVEFYAPWC GHCKNLEPEW AAAASEVKEQ TKGKVKLAAV DATVNQVLAS RYGIRGFPTI KIFQKGESPV DYDGGRTRSD IVSRALDLFS DNAPPPELLE IINEDIAKRT CEEHQLCVVA VLPHILDTGA AGRNSYLEVL LKLADKYKKK MWGWLWTEAG AQSELETALG IGGFGYPAMA AINARKMKFA LLKGSFSEQG INEFLRELSF GRGSTAPVGG GAFPTIVERE PWDGRDGELP VEGDIDLSDV ELDDLGKDEL

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protein disulfide isomerase family A, member 6

Introduction

PDIA6 is a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity.

Entrez Gene ID

10130

UniProt ID

Q15084

Alternative Names

Protein Disulfide Isomerase Family A Member 6; Thioredoxin Domain Containing 7 (Protein Disulfide Isomerase); Protein Disulfide Isomerase-Related Protein; Protein Disulfide Isomerase-Associated 6; Thioredoxin Domain-Containing Protein 7; Endoplasmic Reticulum Protein 5; Protein Disulfide Isomerase P5; ER Protein 5;

Function

May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115).
Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390).
May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390).
Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Biological Process

Protein foldingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Endoplasmic reticulum lumen
Cell membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-PDIA6 Recombinant Antibody (CBYC-P267) (CAT#: CBMAB-P1308-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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