Sign in or Register   Sign in or Register
  |  

Mouse Anti-PDIA6 Recombinant Antibody (3B4) (CBMAB-P1307-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Disulfide Isomerase Family A Member 6. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PDIA6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PDIA6 (AAH01312, 1-440 aa) full length recombinant protein with GST tag. Immunogen sequence: MALLVLGLVS CTFFLAVNGL YSSSDDVIEL TPSNFNREVI QSDSLWLVEF YAPWCGHCQR LTPEWKKAAT ALKDVVKVGA VDADKHHSLG GQYGVQGFPT IKIFGSNKNR PEDYQGGRTG EAIVDAALSA LRQLVKDRLG GRSGGYSSGK QGRSDSSSKK DVIELTDDSF DRNVLDSEDV WMVEFYAPWC GHCKNLEPEW AAAASEVKEQ TKGKVKLAAV DATVNQVLAS RYGIRGFPTI KIFQKGESPV DYDGGRTRSD IVSRALDLFS DNAPPPELLE IINEDIAKRT CEEHQLCVVA VLPHILDTGA AGRNSYLEVL LKLADKYKKK MWGWLWTEAG AQSELETALG IGGFGYPAMA AINARKMKFA LLKGSFSEQG INEFLRELSF GRGSTAPVGG GAFPTIVERE PWDGRDGELP VEGDIDLSDV ELDDLGKDEL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein disulfide isomerase family A, member 6
Introduction
PDIA6 is a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity.
Entrez Gene ID
10130
UniProt ID
Q15084
Alternative Names
Protein Disulfide Isomerase Family A Member 6; Thioredoxin Domain Containing 7 (Protein Disulfide Isomerase); Protein Disulfide Isomerase-Related Protein; Protein Disulfide Isomerase-Associated 6; Thioredoxin Domain-Containing Protein 7; Endoplasmic Reticulum Protein 5; Protein Disulfide Isomerase P5; ER Protein 5;
Function
May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115).
Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390).
May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390).
Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).
Biological Process
Protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endoplasmic reticulum lumen
Cell membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PDIA6 Recombinant Antibody (3B4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare