PFKFB4

PFKFB4 is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival.

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4

Synthesis and degradation of fructose 2,6-bisphosphate.

Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro

Cytosol