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Mouse Anti-PFKFB4 Recombinant Antibody (1C8) (CBMAB-P1510-YC)

Provided herein is a Mouse monoclonal antibody against Human 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4. The antibody can be used for immunoassay techniques, such as ICC, IF, WB.
See all PFKFB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2a
Application
ICC, IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human PFKFB4 (NP_004558) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4
Introduction
PFKFB4 is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival.
Entrez Gene ID
5210
UniProt ID
Q16877
Alternative Names
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4; PF-2-K/Fru-2,6-P2ase Testis-Type Isozyme; PF-2-K/Fru-2,6-P2ase 4; PFK/FBPase 4;
Function
Synthesis and degradation of fructose 2,6-bisphosphate.
Biological Process
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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