PGC

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Progastricsin

Hydrolyzes a variety of proteins.

DigestionManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc

Secreted