PGC

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Full Name
Progastricsin
Function
Hydrolyzes a variety of proteins.
Biological Process
DigestionManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
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Anti-PGC antibodies

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Mouse Anti-PGC Recombinant Antibody (CB182A) (CBMAB-CA182LY)

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Target: PGC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB182A
Application*: ELISA, IHC
Datasheet SDS

Mouse Anti-PGC Recombinant Antibody (1G1H3) (CBMAB-R4270-CN)

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Target: PGC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1H3
Application*: E, IH
Datasheet SDS

Mouse Anti-PGC Recombinant Antibody (CBYC-P321) (CBMAB-P1563-YC)

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Target: PGC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P321
Application*: E
Datasheet SDS

Mouse Anti-PGC Recombinant Antibody (4D7D1) (CBMAB-P1562-YC)

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Target: PGC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D7D1
Application*: E, P
Datasheet SDS

Mouse Anti-PGC Recombinant Antibody (15j162) (CBMAB-P1561-YC)

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Target: PGC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 15j162
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-PGC Recombinant Antibody (CBLG1-2401) (CBMAB-G6445-LY)

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Target: PGC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2401
Application*: E (IA), IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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