PHLPP2

PHLPP2 has broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues.

Full Name

PH Domain And Leucine Rich Repeat Protein Phosphatase 2

Function

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427).
Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499).
Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).

Biological Process

Hippocampus developmentIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Membrane
Nucleus
In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.