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Rabbit Anti-PHLPP2 Recombinant Antibody (SP220) (CBMAB-P1696-YC)

Provided herein is a Rabbit monoclonal antibody against Human PH Domain And Leucine Rich Repeat Protein Phosphatase 2. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all PHLPP2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
SP220
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide derived from human PHLPP2 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PH Domain And Leucine Rich Repeat Protein Phosphatase 2
Introduction
PHLPP2 has broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues.
Entrez Gene ID
23035
UniProt ID
Q6ZVD8
Alternative Names
PH Domain And Leucine Rich Repeat Protein Phosphatase 2; Protein Phosphatase, Mg2+/Mn2+ Dependent 3B; EC 3.1.3.16; PHLPPL; PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase-Like; PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 2;
Function
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427).
Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499).
Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).
Biological Process
Hippocampus developmentIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Membrane
Nucleus
In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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