PLD2

Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM

phospholipase D2

Function as phospholipase selective for phosphatidylcholine (PubMed:9582313).
May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).

Cytoskeleton organizationManual Assertion Based On ExperimentTAS:ProtInc
Fc-gamma receptor signaling pathway involved in phagocytosisTAS:Reactome
Inositol lipid-mediated signalingIEA:InterPro
Phosphatidic acid biosynthetic processTAS:Reactome
Phospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Synaptic vesicle recyclingManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL

Cell membrane

Phosphorylated by FGR.