PLD2

Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM
Full Name
phospholipase D2
Function
Function as phospholipase selective for phosphatidylcholine (PubMed:9582313).
May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentTAS:ProtInc
Fc-gamma receptor signaling pathway involved in phagocytosisTAS:Reactome
Inositol lipid-mediated signalingIEA:InterPro
Phosphatidic acid biosynthetic processTAS:Reactome
Phospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Synaptic vesicle recyclingManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Cellular Location
Cell membrane
PTM
Phosphorylated by FGR.
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Anti-PLD2 antibodies

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Rabbit Anti-PLD2 Recombinant Antibody (E1Y9G) (CBMAB-CP2018-LY)

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Target: PLD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E1Y9G
Application*: WB
Datasheet SDS

Rabbit Anti-PLD2 Recombinant Antibody (E1Y9L) (CBMAB-CP2017-LY)

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Target: PLD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E1Y9L
Application*: P
Datasheet SDS

Mouse Anti-PLD2 Recombinant Antibody (B-3) (CBMAB-P2078-YC)

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Target: PLD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B-3
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PLD2 Recombinant Antibody (7E4D9) (CBMAB-P2077-YC)

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Target: PLD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7E4D9
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-PLD2 Recombinant Antibody (1C5) (CBMAB-P2076-YC)

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Target: PLD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 1C5
Application*: WB, IP, E
Datasheet SDS

Human PLD2 ELISA Kit (V2LY-0626-LY3312)

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Target: PLD2
Sensitivity: 0.29 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-PLD2 Recombinant Antibody (CBT3506) (V2LY-0625-LY481)

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Target: PLD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3506
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-PLD2 Recombinant Antibody (CBT3529) (V2LY-0625-LY480)

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Target: PLD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3529
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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