PLEK2

PLEK2 associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.

Full Name

Pleckstrin 2

Function

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionIEA:InterPro
Positive regulation of plasma membrane bounded cell projection assemblyIEA:Ensembl

Cellular Location

Cell projection, lamellipodium membrane
Cytoplasm, cytoskeleton

Anti-PLEK2 antibodies

Mouse Anti-PLEK2 Recombinant Antibody (5D3) (CBMAB-P2091-YC)

Datasheet

SDS

Target: PLEK2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5D3

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)