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PLXNC1

PLXNC1 is a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma.
Full Name
plexin C1
Function
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 35-944
Helical: 945-965
Cytoplasmic: 966-1568
PTM
N-glycosylated.
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Anti-PLXNC1 antibodies

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Mouse Anti-PLXNC1 Recombinant Antibody (1A12) (CBMAB-A6826-LY)

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Target: PLXNC1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A12
Application*: SE, E
Datasheet SDS

Mouse Anti-PLXNC1 Recombinant Antibody (11n154) (CBMAB-P2211-YC)

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Target: PLXNC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11n154
Application*: IH
Datasheet SDS

Mouse Anti-PLXNC1 Recombinant Antibody (CBT2922) (V2LY-0625-LY1195)

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Target: PLXNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2922
Application*: F
Datasheet SDS

Mouse Anti-PLXNC1 Recombinant Antibody (CBT3407) (V2LY-0625-LY1194)

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Target: PLXNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3407
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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