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Mouse Anti-PLXNC1 Recombinant Antibody (11n154) (CBMAB-P2211-YC)

Provided herein is a Mouse monoclonal antibody against Human Plexin C1. The antibody can be used for immunoassay techniques, such as IHC.
See all PLXNC1 antibodies
Published Data
Fig.1 Cells were passaged and harvested 24 h later for flow cytometry analysis using an anti-human/mouse plexinC1 cross-reacting MAb.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
11n154
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS, trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 49-161

Target

Full Name
plexin C1
Introduction
PLXNC1 is a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma.
Entrez Gene ID
10154
UniProt ID
O60486
Alternative Names
CD232; PLXN-C1; VESPR
Function
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 35-944
Helical: 945-965
Cytoplasmic: 966-1568
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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