PREB

PREB is a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.

Full Name

Prolactin Regulatory Element Binding

Function

Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

Biological Process

COPII vesicle coatingISS:UniProtKB
Endoplasmic reticulum to Golgi vesicle-mediated transportISS:UniProtKB
Protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB
Protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of COPII vesicle coatingManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum membrane
Nucleus
Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).

Topology

Cytoplasmic: 1-388
Helical: 389-409
Lumenal: 410-417