PRR7

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner. Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells.

Full Name

Proline Rich 7, Synaptic

Function

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity).
Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189).
Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222).
Might promote apoptosis in T cells (PubMed:21460222).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Alpha-beta T cell differentiationIEA:Ensembl
Negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Postsynapse to nucleus signaling pathwayIEA:Ensembl
T cell differentiation in thymusIEA:Ensembl

Topology

Extracellular: 1-9
Helical: 10-30
Cytoplasmic: 31-274

PTM

Palmitoylated.
Tyrosine phosphorylated, possibly by SRC.