Mouse Anti-PRR7 Recombinant Antibody (TRAP3/10) (CBMAB-P3043-YC)

Name: Mouse Anti-PRR7 Recombinant Antibody (TRAP3/10)
SKU: CBMAB-P3043-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

TRAP3/10

Application

WB, ICC, IF

Immunogen

Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proline Rich 7, Synaptic

Introduction

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner. Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells.

Entrez Gene ID

Human	80758
Mouse	432763
Rat	498704

UniProt ID

Human	Q8TB68
Mouse	Q3V0I2
Rat	P0C6T3

Alternative Names

Proline Rich 7; Synaptic

Function

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity).
Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189).
Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222).
Might promote apoptosis in T cells (PubMed:21460222).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Alpha-beta T cell differentiationIEA:Ensembl
Negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Postsynapse to nucleus signaling pathwayIEA:Ensembl
T cell differentiation in thymusIEA:Ensembl

Topology

Extracellular: 1-9
Helical: 10-30
Cytoplasmic: 31-274

PTM

Palmitoylated.
Tyrosine phosphorylated, possibly by SRC.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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