Sign in or Register   Sign in or Register
  |  

Mouse Anti-PRR7 Recombinant Antibody (TRAP3/10) (CBMAB-P3043-YC)

Provided herein is a Mouse monoclonal antibody against Human Proline Rich 7, Synaptic. The antibody can be used for immunoassay techniques, such as WB, ICC, IF.
See all PRR7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
TRAP3/10
Antibody Isotype
IgG2a
Application
WB, ICC, IF

Basic Information

Immunogen
Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proline Rich 7, Synaptic
Introduction
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner. Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells.
Entrez Gene ID
Human80758
Mouse432763
Rat498704
UniProt ID
HumanQ8TB68
MouseQ3V0I2
RatP0C6T3
Alternative Names
Proline Rich 7; Synaptic
Function
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity).
Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189).
Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222).
Might promote apoptosis in T cells (PubMed:21460222).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Alpha-beta T cell differentiationIEA:Ensembl
Negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Postsynapse to nucleus signaling pathwayIEA:Ensembl
T cell differentiation in thymusIEA:Ensembl
Topology
Extracellular: 1-9
Helical: 10-30
Cytoplasmic: 31-274
PTM
Palmitoylated.
Tyrosine phosphorylated, possibly by SRC.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PRR7 Recombinant Antibody (TRAP3/10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare