PSKH1

PSKH1 (Protein Serine Kinase H1) is a protein coding gene. Among its related pathways are mRNA Splicing-Major Pathway. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

Full Name

Protein serine kinase H1

Function

May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Biological Process

Determination of left/right symmetryIEA:Ensembl
Heart developmentIEA:Ensembl
Protein phosphorylationIEA:Ensembl

Cellular Location

Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Nucleus speckle
Endoplasmic reticulum membrane
Cell membrane
Cytoplasm
Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.

PTM

Autophosphorylated on serine residues.
Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.
Palmitoylated.