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Rabbit Anti-PSKH1 Recombinant Antibody (EG1810) (CBMAB-EN2170-LY)

The product is antibody recognizes KPSH1. The antibody EG1810 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all PSKH1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1810
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human KPSH1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Protein serine kinase H1
Entrez Gene ID
Human5681
Mouse244631
UniProt ID
HumanP11801
MouseQ91YA2
Function
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.
Biological Process
Determination of left/right symmetryIEA:Ensembl
Heart developmentIEA:Ensembl
Protein phosphorylationIEA:Ensembl
Cellular Location
Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Nucleus speckle
Endoplasmic reticulum membrane
Cell membrane
Cytoplasm
Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.
PTM
Autophosphorylated on serine residues.
Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.
Palmitoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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