PSMA8

PSMA8 (Proteasome Subunit Alpha 8) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of the gene is PSMA7.

Full Name

proteasome (prosome, macropain) subunit, alpha type, 8

Function

Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.

Biological Process

Cell differentiationIEA:UniProtKB-KW
Meiotic cell cycleISS:UniProtKB
Proteasomal protein catabolic processISS:UniProtKB
Regulation of meiosis IIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW
Ubiquitin-dependent protein catabolic processIEA:InterPro

Cellular Location

Nucleus
Localizes to the central region of the synaptonemal complex.