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Mouse Anti-PSMA8 Recombinant Antibody (2E3) (CBMAB-P3157-YC)

Provided herein is a Mouse monoclonal antibody against Human Proteasome Subunit Alpha 8. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PSMA8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2E3
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa143-243 from human PSMA8 (NP_653263) with GST tag.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proteasome (prosome, macropain) subunit, alpha type, 8
Introduction
PSMA8 (Proteasome Subunit Alpha 8) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of the gene is PSMA7.
Entrez Gene ID
Human143471
Mouse73677
Rat364814
UniProt ID
HumanQ8TAA3
MouseQ9CWH6
RatF1M6I7
Alternative Names
PSMA7L
Function
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Biological Process
Cell differentiationIEA:UniProtKB-KW
Meiotic cell cycleISS:UniProtKB
Proteasomal protein catabolic processISS:UniProtKB
Regulation of meiosis IIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW
Ubiquitin-dependent protein catabolic processIEA:InterPro
Cellular Location
Nucleus
Localizes to the central region of the synaptonemal complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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