PSMC3IP

PSMC3IP plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.

Full Name

PSMC3 Interacting Protein

Function

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.

Biological Process

Homologous chromosome pairing at meiosisManual Assertion Based On ExperimentIDA:ComplexPortal
Meiotic joint molecule formationManual Assertion Based On ExperimentIBA:GO_Central
Meiotic strand invasion involved in reciprocal meiotic recombinationManual Assertion Based On ExperimentIBA:GO_Central
Reciprocal meiotic recombinationManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Nucleus

Involvement in disease

Ovarian dysgenesis 3 (ODG3):
A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.

PTM

PTM: Phosphorylated by PKA, PKC and MAPK.